This paper presents a dedicated approach to the calculation of the random response of assemblies with uncertain interface characteristics. The random response is constructed using a polynomial chaos expansion (PCE). A decomposition of the assemblies into substructures and interfaces is defined and associated with a dedicated computational strategy which leads to a local/global algorithm enabling the treatments of the substructure and of the interface problems to be uncoupled. Since the only uncertain parameters are those which appear in the interface equations, this approach results in a drastic reduction of the computational costs. This paper first presents the classical stochastic finite element strategy for this kind of problem, then details the proposed dedicated approach. The applications concern structures assembled with uncertain elastic bonded joints. The proposed approach is compared to the Monte Carlo method and to the stochastic finite element method.