The core-specific lysosomal alpha(1-6)-mannosidase activity depends on aspartamidohydrolase activity - Université du Littoral Côte d'Opale Access content directly
Journal Articles Biochemical Journal Year : 1993

The core-specific lysosomal alpha(1-6)-mannosidase activity depends on aspartamidohydrolase activity

Abstract

The substrate specificity of the core-specific rat liver lysosomal alpha(1-6)-mannosidase was investigated using mannosylated oligosaccharides and glycoasparagines. Hydrolysis of Man(alpha 1-6) linkage hydrolysis was demonstrated to follow the action of endoglycosidases, namely aspartyl-N-acetyl-beta-D-glucosaminidase and endo-N-acetyl-beta-D-glucosaminidase. The results are discussed with respect to the nature of the carbohydrate materials stored in the tissues and excreted in the urine from patients suffering from aspartylglucosaminuria and fucosidosis.

Dates and versions

hal-03697234 , version 1 (20-06-2022)

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Jean-Franois Haeuw, Thierry Grard, Catherine Alonso, Jean-Claude Michalski. The core-specific lysosomal alpha(1-6)-mannosidase activity depends on aspartamidohydrolase activity. Biochemical Journal, 1993, 297 (3), pp.463-466. ⟨10.1042/bj2970463⟩. ⟨hal-03697234⟩

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CNRS UNIV-LITTORAL
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