Bent-core liquid crystals (BCLC) have been widely studied as a result of their unusual polar and chiral properties. Similar to calamitic and discotic molecules, BCLC molecules also exhibit nematic phases, besides other higher order mesophases. The aim of this work is to comparatively analyze the mesomorphic behavior of some bent-core 1,3-disubstituted benzene core compounds derived from resorcinol and isophthalic acid. Thus, the two classes of compounds differ in the nature of the orientation of the ester bond between the benzene central core and the two branches attached to the core. The mesomorphic behavior was elucidated by polarized light optical microscopy and differential calorimetry. Given the relatively high isotropic points of the compounds, confirmation of the thermal stability in the domains manifesting liquid crystalline properties was performed by thermogravimetric studies. The theoretical explanation of the difference in mesomorphic behavior for the two classes was based on molecular modeling studies.