The present study focuses on the morphosedimentary organization and sediment infilling stratigraphy of one of the largest estuaries of southern Patagonia in Argentina. With a tidal range up to 12 m, the area is subject to extreme tidal conditions, combined with moderate offshore wave climate, strong and constant westerly winds, and contrasted water and sediment discharges from the two tributaries of the estuary, the Santa Cruz and Chico Rivers. The estuarine valley is entrenched in the Patagonian coastal plateau due to significant uplift. On the basis of sediment facies (sedimentary structures, grain size, geochemistry, mineralogy), meiofauna (foraminifera and testate amoebae), morphological changes and shallow geophysics (high-resolution seismic reflection, ground-penetrating radar) data, the Santa Cruz-Chico River system is defined as a hybrid system comprising a tide-influenced fluvial mouth (the Santa Cruz River) and a tide-dominated estuary (the Chico River estuary), both converging towards an elongated subtidal ria-type estuarine basin. River-supplied sands and muds by-pass the estuarine basin and are exported offshore where they settle and form an ebb-tidal delta. Sediments in the Santa Cruz-Chico River valley mainly consists of Pleistocene lowstand fluvial gravels resting on the regional Miocene substrate, and thin early Holocene transgressive deposits, deeply incised by a tidal ravinement surface that developed during the highest Holocene sea-level at ca 7500 yr. BP. After the maximumstillstand, relative sea level fell and a competition occurred between erosion, promoted by water depth decrease, and deposition, favoured by tidal prism reduction. At present, sediment by-passing and offshore sediment export are the dominant processes. The very large size of the ebb-tidal delta, which expands on the continental shelf, suggests that this situation has prevailed for a very long time.